TY  - GEN
AU  - Sheahan,Timothy P
AU  - Sims,Amy C
AU  - Zhou,Shuntai
AU  - Graham,Rachel L
AU  - Pruijssers,Andrea J
AU  - Agostini,Maria L
AU  - Leist,Sarah R
AU  - Schäfer,Alexandra
AU  - Dinnon,Kenneth H
AU  - Stevens,Laura J
AU  - Chappell,James D
AU  - Lu,Xiaotao
AU  - Hughes,Tia M
AU  - George,Amelia S
AU  - Hill,Collin S
AU  - Montgomery,Stephanie A
AU  - Brown,Ariane J
AU  - Bluemling,Gregory R
AU  - Natchus,Michael G
AU  - Saindane,Manohar
AU  - Kolykhalov,Alexander A
AU  - Painter,George
AU  - Harcourt,Jennifer
AU  - Tamin,Azaibi
AU  - Thornburg,Natalie J
AU  - Swanstrom,Ronald
AU  - Denison,Mark R
AU  - Baric,Ralph S
TI  - An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
SN  - 1946-6242
PY  - 2020///0504
KW  - Adenosine Monophosphate
KW  - administration & dosage
KW  - Alanine
KW  - Animals
KW  - Antibiotic Prophylaxis
KW  - Antiviral Agents
KW  - Betacoronavirus
KW  - physiology
KW  - COVID-19
KW  - Cell Line
KW  - Coronavirus Infections
KW  - drug therapy
KW  - Cytidine
KW  - Disease Models, Animal
KW  - Drug Resistance, Viral
KW  - Humans
KW  - Hydroxylamines
KW  - Lung
KW  - pathology
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Middle East Respiratory Syndrome Coronavirus
KW  - Models, Molecular
KW  - Mutation
KW  - drug effects
KW  - Pandemics
KW  - Pneumonia, Viral
KW  - Primary Cell Culture
KW  - RNA, Viral
KW  - RNA-Dependent RNA Polymerase
KW  - chemistry
KW  - Random Allocation
KW  - Respiratory System
KW  - cytology
KW  - Ribonucleosides
KW  - SARS-CoV-2
KW  - Virus Replication
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1126/scitranslmed.abb5883
ER  -