Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America 04 2020
- 8515-8523 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1091-6490
10.1073/pnas.1910952117 doi
Anaphylatoxins--metabolism Animals Antineoplastic Agents--pharmacology Apoptosis Cancer-Associated Fibroblasts--drug effects DNA, Mitochondrial--metabolism Docetaxel--pharmacology Drug Resistance, Neoplasm Epithelium--drug effects Humans Male Mice Mice, Inbred C57BL Mice, Nude Paracrine Communication Prostatic Neoplasms--drug therapy Toll-Like Receptor 9--metabolism Tumor Cells, Cultured Xenograft Model Antitumor Assays