TY  - GEN
AU  - Krystal,Andrew D
AU  - Pizzagalli,Diego A
AU  - Smoski,Moria
AU  - Mathew,Sanjay J
AU  - Nurnberger,John
AU  - Lisanby,Sarah H
AU  - Iosifescu,Dan
AU  - Murrough,James W
AU  - Yang,Hongqiu
AU  - Weiner,Richard D
AU  - Calabrese,Joseph R
AU  - Sanacora,Gerard
AU  - Hermes,Gretchen
AU  - Keefe,Richard S E
AU  - Song,Allen
AU  - Goodman,Wayne
AU  - Szabo,Steven T
AU  - Whitton,Alexis E
AU  - Gao,Keming
AU  - Potter,William Z
TI  - A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia
SN  - 1546-170X
PY  - 2020///0824
KW  - Adult
KW  - Anhedonia
KW  - drug effects
KW  - Anxiety Disorders
KW  - complications
KW  - Benzamides
KW  - therapeutic use
KW  - Central Nervous System Agents
KW  - Double-Blind Method
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Mood Disorders
KW  - Narcotic Antagonists
KW  - Proof of Concept Study
KW  - Pyrrolidines
KW  - Receptors, Opioid, kappa
KW  - antagonists & inhibitors
KW  - Time Factors
KW  - Treatment Outcome
N1  - Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
UR  - https://doi.org/10.1038/s41591-020-0806-7
ER  -