TY  - GEN
AU  - Inoue,Chisato
AU  - Sobue,Sayaka
AU  - Kawamoto,Yoshiyuki
AU  - Nishizawa,Yuji
AU  - Ichihara,Masatoshi
AU  - Abe,Akihiro
AU  - Hayakawa,Fumihiko
AU  - Suzuki,Motoshi
AU  - Nozawa,Yoshinori
AU  - Murate,Takahsi
TI  - Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells
SN  - 1090-2104
PY  - 2020///1228
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Cell Death
KW  - drug effects
KW  - Cell Line, Tumor
KW  - Cyclin D2
KW  - genetics
KW  - Drug Resistance, Neoplasm
KW  - Drug Synergism
KW  - Glycogen Synthase Kinase 3
KW  - antagonists & inhibitors
KW  - Humans
KW  - Imatinib Mesylate
KW  - Imidazoles
KW  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive
KW  - drug therapy
KW  - Leupeptins
KW  - Macrocyclic Compounds
KW  - Myeloid Cell Leukemia Sequence 1 Protein
KW  - Phosphatidylinositol 3-Kinases
KW  - metabolism
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Phosphorylation
KW  - Protein Kinase Inhibitors
KW  - Protein Phosphatase 2
KW  - Proteolysis
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - Proto-Oncogene Proteins c-myc
KW  - Pyridazines
KW  - Pyrroles
KW  - Signal Transduction
KW  - Wortmannin
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bbrc.2020.02.165
ER  -