TY - GEN AU - Chen,Wenbo AU - Boras,Britton AU - Sung,Tae AU - Yu,Yanke AU - Zheng,Jenny AU - Wang,Diane AU - Hu,Wenyue AU - Spilker,Mary E AU - D'Argenio,David Z TI - A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor SN - 1573-8744 PY - 2021///0430 KW - Algorithms KW - Antineoplastic Agents KW - pharmacology KW - Bone Marrow KW - drug effects KW - Cell Cycle KW - Cell Movement KW - Filgrastim KW - Granulocyte Colony-Stimulating Factor KW - Granulocytes KW - Hematopoiesis KW - Humans KW - Leukocyte Count KW - Models, Biological KW - Neutropenia KW - chemically induced KW - Neutrophils KW - Piperazines KW - Polyethylene Glycols KW - Pyridines KW - Stem Cells N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1007/s10928-020-09680-6 ER -