A Computational Pipeline to Predict Cardiotoxicity: From the Atom to the Rhythm. [electronic resource]
- Circulation research 04 2020
- 947-964 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1524-4571
10.1161/CIRCRESAHA.119.316404 doi
Anti-Arrhythmia Agents--chemistry Arrhythmias, Cardiac--drug therapy Cardiotoxicity--metabolism Cardiotoxins--adverse effects Computer Simulation Drug Discovery--methods ERG1 Potassium Channel--chemistry Female Humans Long QT Syndrome--drug therapy Machine Learning Male Moxifloxacin--chemistry Myocytes, Cardiac--drug effects Phenethylamines--chemistry Protein Structure, Secondary Sulfonamides--chemistry Topoisomerase II Inhibitors--chemistry