TY - GEN AU - El-Sisi,Alaa E AU - Sokkar,Samia S AU - Ibrahim,Hanaa A AU - Hamed,Mohamed F AU - Abu-Risha,Sally E TI - Targeting MDR-1 gene expression, BAX/BCL2, caspase-3, and Ki-67 by nanoencapsulated imatinib and hesperidin to enhance anticancer activity and ameliorate cardiotoxicity SN - 1472-8206 PY - 2021///0420 KW - ATP Binding Cassette Transporter, Subfamily B, Member 1 KW - genetics KW - Animals KW - Antineoplastic Combined Chemotherapy Protocols KW - chemistry KW - Breast Neoplasms KW - drug therapy KW - Carcinoma, Ehrlich Tumor KW - Cardiotoxicity KW - Caspase 3 KW - metabolism KW - Drug Carriers KW - Drug Compounding KW - Female KW - Heart Diseases KW - chemically induced KW - Humans KW - Imatinib Mesylate KW - Indoles KW - Ki-67 Antigen KW - MCF-7 Cells KW - Mice KW - Nanoparticles KW - Polylactic Acid-Polyglycolic Acid Copolymer KW - Proto-Oncogene Proteins c-bcl-2 KW - Signal Transduction KW - Sulfonamides KW - Tumor Burden KW - drug effects KW - bcl-2-Associated X Protein N1 - Publication Type: Comparative Study; Journal Article UR - https://doi.org/10.1111/fcp.12549 ER -