TY  - GEN
AU  - El Ashry,El Sayed Helmy
AU  - Awad,Laila Fathy
AU  - Teleb,Mohamed
AU  - Ibrahim,Nihal Ahmed
AU  - Abu-Serie,Marwa M
AU  - Abd Al Moaty,Mohamed Nabil
TI  - Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology
SN  - 1090-2120
PY  - 2021///0224
KW  - Cell Line, Tumor
KW  - Drug Design
KW  - Drug Screening Assays, Antitumor
KW  - Humans
KW  - Matrix Metalloproteinase 10
KW  - metabolism
KW  - Matrix Metalloproteinase 13
KW  - Matrix Metalloproteinase Inhibitors
KW  - chemistry
KW  - Molecular Docking Simulation
KW  - Neoplasms
KW  - drug therapy
KW  - Polypharmacology
KW  - Pyridines
KW  - Structure-Activity Relationship
KW  - Triazoles
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bioorg.2020.103616
ER  -