El Ashry, El Sayed Helmy <br/><br/>
Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology.  [electronic resource] 

 -  Bioorganic chemistry  03 2020 
 - 103616 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1090-2120 
<br/><br/><label>Standard No.: </label>10.1016/j.bioorg.2020.103616  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Cell Line, Tumor<br/>Drug Design<br/>Drug Screening Assays, Antitumor<br/>Humans<br/>Matrix Metalloproteinase 10--metabolism<br/>Matrix Metalloproteinase 13--metabolism<br/>Matrix Metalloproteinase Inhibitors--chemistry<br/>Molecular Docking Simulation<br/>Neoplasms--drug therapy<br/>Polypharmacology<br/>Pyridines--chemistry<br/>Structure-Activity Relationship<br/>Triazoles--chemistry