TY - GEN AU - Li,Yang AU - Gruber,Joshua J AU - Litzenburger,Ulrike M AU - Zhou,Yiren AU - Miao,Yu Rebecca AU - LaGory,Edward L AU - Li,Albert M AU - Hu,Zhen AU - Yip,Michaela AU - Hart,Lori S AU - Maris,John M AU - Chang,Howard Y AU - Giaccia,Amato J AU - Ye,Jiangbin TI - Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia SN - 2041-4889 PY - 2021///0309 KW - Acetates KW - pharmacology KW - Acetylation KW - Animals KW - Antineoplastic Agents KW - Cell Line, Tumor KW - Chromatin Assembly and Disassembly KW - drug effects KW - Gene Expression Regulation, Neoplastic KW - Histones KW - metabolism KW - Humans KW - Male KW - Mice KW - Neuroblastoma KW - drug therapy KW - Neurogenesis KW - Neuronal Outgrowth KW - Pyruvate Dehydrogenase Acetyl-Transferring Kinase KW - genetics KW - Signal Transduction KW - Tumor Burden KW - Tumor Hypoxia KW - Tumor Microenvironment KW - Warburg Effect, Oncologic KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41419-020-2303-9 ER -