TY  - GEN
AU  - Quijada-Álamo,Miguel
AU  - Hernández-Sánchez,María
AU  - Alonso-Pérez,Verónica
AU  - Rodríguez-Vicente,Ana E
AU  - García-Tuñón,Ignacio
AU  - Martín-Izquierdo,Marta
AU  - Hernández-Sánchez,Jesús María
AU  - Herrero,Ana B
AU  - Bastida,José María
AU  - San Segundo,Laura
AU  - Gruber,Michaela
AU  - García,Juan Luis
AU  - Yin,Shanye
AU  - Ten Hacken,Elisa
AU  - Benito,Rocío
AU  - Ordóñez,José Luis
AU  - Wu,Catherine J
AU  - Hernández-Rivas,Jesús María
TI  - CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition
SN  - 1476-5551
PY  - 2020///1007
KW  - Adenine
KW  - analogs & derivatives
KW  - Animals
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - pharmacology
KW  - Ataxia Telangiectasia Mutated Proteins
KW  - genetics
KW  - CRISPR-Cas Systems
KW  - Cell Line, Tumor
KW  - Chromosome Deletion
KW  - Chromosomes, Human, Pair 11
KW  - Drug Synergism
KW  - Humans
KW  - Leukemia, Lymphocytic, Chronic, B-Cell
KW  - Mice
KW  - Mutagenesis, Site-Directed
KW  - methods
KW  - Mutation
KW  - Phthalazines
KW  - Piperazines
KW  - Piperidines
KW  - Poly (ADP-Ribose) Polymerase-1
KW  - antagonists & inhibitors
KW  - Poly(ADP-ribose) Polymerase Inhibitors
KW  - Proto-Oncogene Proteins c-bcr
KW  - Pyrazoles
KW  - Pyrimidines
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41375-020-0714-3
ER  -