TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. [electronic resource]
- Nature communications 01 2020
- 348 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-019-14190-2 doi
Animals Carcinoma, Hepatocellular--genetics Cell Line, Tumor Cell Survival--physiology Endoplasmic Reticulum Stress--physiology Endoribonucleases--metabolism Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Kelch-Like ECH-Associated Protein 1--metabolism Liver Liver Neoplasms--genetics Male Mice Mice, Inbred BALB C Mice, Nude NF-E2-Related Factor 2--metabolism Oxidative Stress Protein Serine-Threonine Kinases--metabolism Signal Transduction Transcription Factors--genetics Tripartite Motif Proteins--genetics Ubiquitin-Protein Ligases--genetics Xenograft Model Antitumor Assays