TY  - GEN
AU  - Goyard,David
AU  - Kónya,Bálint
AU  - Czifrák,Katalin
AU  - Larini,Paolo
AU  - Demontrond,Fanny
AU  - Leroy,Jérémy
AU  - Balzarin,Sophie
AU  - Tournier,Michel
AU  - Tousch,Didier
AU  - Petit,Pierre
AU  - Duret,Cédric
AU  - Maurel,Patrick
AU  - Docsa,Tibor
AU  - Gergely,Pál
AU  - Somsák,László
AU  - Praly,Jean-Pierre
AU  - Azay-Milhau,Jacqueline
AU  - Vidal,Sébastien
TI  - Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition
SN  - 1477-0539
PY  - 2020///0924
KW  - Animals
KW  - Blood Glucose
KW  - metabolism
KW  - Cyclization
KW  - Density Functional Theory
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Glucose
KW  - Glycogen
KW  - Glycogen Phosphorylase
KW  - antagonists & inhibitors
KW  - Hepatocytes
KW  - drug effects
KW  - Humans
KW  - Hypoglycemic Agents
KW  - chemical synthesis
KW  - Inhibitory Concentration 50
KW  - Kinetics
KW  - Lactones
KW  - Oxidation-Reduction
KW  - Rats, Zucker
KW  - Spiro Compounds
KW  - Stereoisomerism
KW  - Temperature
KW  - Thiazoles
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1039/c9ob01190k
ER  -