TY - GEN AU - Nugent,Alicia A AU - Lin,Karin AU - van Lengerich,Bettina AU - Lianoglou,Steve AU - Przybyla,Laralynne AU - Davis,Sonnet S AU - Llapashtica,Ceyda AU - Wang,Junhua AU - Kim,Do Jin AU - Xia,Dan AU - Lucas,Anthony AU - Baskaran,Sulochanadevi AU - Haddick,Patrick C G AU - Lenser,Melina AU - Earr,Timothy K AU - Shi,Ju AU - Dugas,Jason C AU - Andreone,Benjamin J AU - Logan,Todd AU - Solanoy,Hilda O AU - Chen,Hang AU - Srivastava,Ankita AU - Poda,Suresh B AU - Sanchez,Pascal E AU - Watts,Ryan J AU - Sandmann,Thomas AU - Astarita,Giuseppe AU - Lewcock,Joseph W AU - Monroe,Kathryn M AU - Di Paolo,Gilbert TI - TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge SN - 1097-4199 PY - 2020///0707 KW - Acetyl-CoA C-Acetyltransferase KW - antagonists & inhibitors KW - Alzheimer Disease KW - genetics KW - Animals KW - Brain KW - metabolism KW - Cholesterol KW - Cholesterol Esters KW - Disease Models, Animal KW - Flow Cytometry KW - Humans KW - Induced Pluripotent Stem Cells KW - Lipid Metabolism KW - Lipidomics KW - Liver X Receptors KW - agonists KW - Macrophages KW - Membrane Glycoproteins KW - Mice KW - Mice, Knockout KW - Mice, Knockout, ApoE KW - Microglia KW - Myelin Sheath KW - Phagocytosis KW - RNA-Seq KW - Receptors, Immunologic N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.neuron.2019.12.007 ER -