Ng, Sheng Rong

CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America 01 2020 - 513-521 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1091-6490

10.1073/pnas.1821893117 doi


Animals
Apoptosis--genetics
CRISPR-Cas Systems--genetics
Cell Line
Cell Proliferation--genetics
Disease Models, Animal
Disease Progression
Feasibility Studies
Gene Editing--methods
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Loss of Function Mutation
Lung--pathology
Lung Neoplasms--genetics
Mice
Mice, Transgenic
Neoplasm Staging
Retinoblastoma-Like Protein p107--genetics
Retinoblastoma-Like Protein p130--genetics
Small Cell Lung Carcinoma--genetics
Tumor Burden--genetics
Tumor Suppressor Protein p53--genetics