CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America 01 2020
- 513-521 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1821893117 doi
Animals Apoptosis--genetics CRISPR-Cas Systems--genetics Cell Line Cell Proliferation--genetics Disease Models, Animal Disease Progression Feasibility Studies Gene Editing--methods Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Humans Loss of Function Mutation Lung--pathology Lung Neoplasms--genetics Mice Mice, Transgenic Neoplasm Staging Retinoblastoma-Like Protein p107--genetics Retinoblastoma-Like Protein p130--genetics Small Cell Lung Carcinoma--genetics Tumor Burden--genetics Tumor Suppressor Protein p53--genetics