TY  - GEN
AU  - O'Connell,James
AU  - Porter,John
AU  - Kroeplien,Boris
AU  - Norman,Tim
AU  - Rapecki,Stephen
AU  - Davis,Rachel
AU  - McMillan,David
AU  - Arakaki,Tracy
AU  - Burgin,Alex
AU  - Fox Iii,David
AU  - Ceska,Tom
AU  - Lecomte,Fabien
AU  - Maloney,Alison
AU  - Vugler,Alex
AU  - Carrington,Bruce
AU  - Cossins,Benjamin P
AU  - Bourne,Tim
AU  - Lawson,Alastair
TI  - Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer
SN  - 2041-1723
PY  - 2020///0406
KW  - Animals
KW  - Anti-Inflammatory Agents
KW  - pharmacology
KW  - Arthritis, Experimental
KW  - drug therapy
KW  - Cell Line
KW  - Crystallography, X-Ray
KW  - Drug Discovery
KW  - Male
KW  - Mice
KW  - Molecular Dynamics Simulation
KW  - Neutrophil Infiltration
KW  - drug effects
KW  - Neutrophils
KW  - Protein Multimerization
KW  - Protein Stability
KW  - Protein Structure, Quaternary
KW  - Receptors, Tumor Necrosis Factor, Type I
KW  - immunology
KW  - Recombinant Proteins
KW  - isolation & purification
KW  - Signal Transduction
KW  - Structure-Activity Relationship
KW  - Treatment Outcome
KW  - Tumor Necrosis Factor-alpha
KW  - antagonists & inhibitors
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41467-019-13616-1
ER  -