Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments. [electronic resource]
- PloS one 2019
- e0225660 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0225660 doi
Antineoplastic Combined Chemotherapy Protocols--administration & dosage Apoptosis--drug effects Berberine--administration & dosage Biological Availability Brain Neoplasms--drug therapy Cell Line, Tumor Cell Proliferation--drug effects Cell Survival--drug effects Curcumin--administration & dosage Drug Carriers--chemistry Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Drug Synergism Glioblastoma--drug therapy Humans Lipids--chemistry Phosphatidylinositol 3-Kinases--metabolism Proto-Oncogene Proteins c-akt--metabolism Signal Transduction--drug effects TOR Serine-Threonine Kinases--metabolism