TY  - GEN
AU  - Lau,Anthony
AU  - Avery,Danielle T
AU  - Jackson,Katherine
AU  - Lenthall,Helen
AU  - Volpi,Stefano
AU  - Brigden,Henry
AU  - Russell,Amanda J
AU  - Bier,Julia
AU  - Reed,Joanne H
AU  - Smart,Joanne M
AU  - Cole,Theresa
AU  - Choo,Sharon
AU  - Gray,Paul E
AU  - Berglund,Lucinda J
AU  - Hsu,Peter
AU  - Wong,Melanie
AU  - O'Sullivan,Michael
AU  - Boztug,Kaan
AU  - Meyts,Isabelle
AU  - Uzel,Gulbu
AU  - Notarangelo,Luigi D
AU  - Brink,Robert
AU  - Goodnow,Christopher C
AU  - Tangye,Stuart G
AU  - Deenick,Elissa K
TI  - Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production
SN  - 1540-9538
PY  - 2020///0909
KW  - Animals
KW  - Antibody Formation
KW  - genetics
KW  - Autoantibodies
KW  - blood
KW  - Autoantigens
KW  - immunology
KW  - Autoimmunity
KW  - Class I Phosphatidylinositol 3-Kinases
KW  - Female
KW  - Gain of Function Mutation
KW  - Germinal Center
KW  - Humans
KW  - Immune Tolerance
KW  - Immunoglobulin M
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Transgenic
KW  - Plasma Cells
KW  - Signal Transduction
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1084/jem.20191336
ER  -