Yang, Gui-Xiang
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. [electronic resource]
- European journal of medicinal chemistry Feb 2020
- 111913 p. digital
Publication Type: Journal Article
ISSN: 1768-3254
Standard No.: 10.1016/j.ejmech.2019.111913 doi
Subjects--Topical Terms: Aging--drug effects Alzheimer Disease--drug therapy Amyloid beta-Peptides--antagonists & inhibitors Animals Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis Astrocytes--drug effects Carbamates--chemical synthesis Cell Line, Tumor Cell Survival--drug effects Diosgenin--chemical synthesis Dose-Response Relationship, Drug Drug Design Galactose--administration & dosage Humans Inflammation--drug therapy Male Mice Mice, Inbred ICR Molecular Structure Neuroprotective Agents--chemical synthesis Oxidative Stress--drug effects Protein Aggregates--drug effects Structure-Activity Relationship