A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. [electronic resource]
- Nature communications 11 2019
- 5444 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-019-13334-8 doi
A549 Cells Carcinoma, Non-Small-Cell Lung--metabolism Cell Line, Tumor Class I Phosphatidylinositol 3-Kinases--drug effects Cyclin-Dependent Kinases--antagonists & inhibitors Glucose--metabolism Glucose Transporter Type 1--drug effects High-Throughput Screening Assays Humans Lung Neoplasms--metabolism Phenylenediamines--pharmacology Phosphorylation Protein Kinase Inhibitors--pharmacology Pyrazoles--pharmacology Pyrimidines--pharmacology Quinazolines--pharmacology RNA Polymerase II--drug effects RNA, Messenger--metabolism Signal Transduction Triazines--pharmacology Cyclin-Dependent Kinase-Activating Kinase