TY - GEN AU - Lercher,Alexander AU - Bhattacharya,Anannya AU - Popa,Alexandra M AU - Caldera,Michael AU - Schlapansky,Moritz F AU - Baazim,Hatoon AU - Agerer,Benedikt AU - Gürtl,Bettina AU - Kosack,Lindsay AU - Májek,Peter AU - Brunner,Julia S AU - Vitko,Dijana AU - Pinter,Theresa AU - Genger,Jakob-Wendelin AU - Orlova,Anna AU - Pikor,Natalia AU - Reil,Daniela AU - Ozsvár-Kozma,Maria AU - Kalinke,Ulrich AU - Ludewig,Burkhard AU - Moriggl,Richard AU - Bennett,Keiryn L AU - Menche,Jörg AU - Cheng,Paul N AU - Schabbauer,Gernot AU - Trauner,Michael AU - Klavins,Kristaps AU - Bergthaler,Andreas TI - Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function SN - 1097-4180 PY - 2020///0130 KW - Animals KW - Arginine KW - blood KW - CD4-Positive T-Lymphocytes KW - immunology KW - CD8-Positive T-Lymphocytes KW - Cell Line KW - Chlorocebus aethiops KW - Cricetinae KW - Female KW - Hepatocytes KW - metabolism KW - Interferon Type I KW - Liver KW - Lymphocytic Choriomeningitis KW - Lymphocytic choriomeningitis virus KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Ornithine KW - Ornithine Carbamoyltransferase KW - genetics KW - Receptor, Interferon alpha-beta KW - Signal Transduction KW - Urea KW - Vero Cells N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.immuni.2019.10.014 ER -