Kaymak, Irem <br/><br/>
Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.  [electronic resource] 

 -  Cancer research  01 2020 
 - 189-203 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1538-7445 
<br/><br/><label>Standard No.: </label>10.1158/0008-5472.CAN-19-0650  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis<br/>Cell Line, Tumor<br/>Cell Survival<br/>Citric Acid Cycle--drug effects<br/>Humans<br/>Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology<br/>Intestinal Mucosa--cytology<br/>Mevalonic Acid--metabolism<br/>Mice<br/>Mice, Transgenic<br/>Neoplasms--genetics<br/>Pyrimidines--metabolism<br/>Signal Transduction--drug effects<br/>Sterol Regulatory Element Binding Protein 2--metabolism<br/>Stress, Physiological<br/>Tumor Microenvironment--genetics<br/>Tumor Suppressor Protein p53--genetics<br/>Ubiquinone--analogs & derivatives<br/>Xenograft Model Antitumor Assays