Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors. [electronic resource]
- Osteoarthritis and cartilage 05 2020
- 658-668 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1522-9653
10.1016/j.joca.2019.11.002 doi
ADAMTS5 Protein--drug effects Aged Aged, 80 and over Aggrecans--metabolism Blotting, Western Cartilage, Articular--drug effects Female Humans In Vitro Techniques Inflammation--metabolism Interleukin-6--metabolism Lipid A--pharmacology Lipopeptides--pharmacology Male Matrix Metalloproteinase 3--drug effects Middle Aged Oligopeptides--pharmacology Single-Domain Antibodies--pharmacology Synovial Membrane--drug effects Toll-Like Receptor 2--agonists Toll-Like Receptor 4--agonists Toll-Like Receptor 9--agonists Tumor Necrosis Factor-alpha--pharmacology