Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis. [electronic resource]
- International immunopharmacology Dec 2019
- 105968 p. digital
Publication Type: Journal Article
1878-1705
10.1016/j.intimp.2019.105968 doi
Abietanes--pharmacology Animals Bleomycin--pharmacology Cell Line Disease Models, Animal Endothelial Cells--drug effects Endothelium--drug effects Epithelial-Mesenchymal Transition--drug effects Female Fibrosis--drug therapy Human Umbilical Vein Endothelial Cells Humans Mice Mice, Inbred C57BL Proto-Oncogene Proteins c-akt--metabolism Ribosomal Protein S6 Kinases, 70-kDa--metabolism Salvia miltiorrhiza--chemistry Scleroderma, Systemic--metabolism Signal Transduction--drug effects TOR Serine-Threonine Kinases--metabolism