Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth. [electronic resource]
- Cancer research 01 2020
- 319-333 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-7445
10.1158/0008-5472.CAN-19-1023 doi
AMP-Activated Protein Kinases--metabolism Adult Aged Aged, 80 and over Amino Acids, Branched-Chain--analysis Animals Carcinogenesis--genetics Carcinoma, Renal Cell--genetics Cell Line, Tumor Cell Movement--genetics Cell Proliferation Down-Regulation Enoyl-CoA Hydratase--metabolism Fatty Acids--analysis Female GATA3 Transcription Factor--metabolism Gene Expression Regulation, Neoplastic HEK293 Cells Humans Kidney--pathology Kidney Neoplasms--genetics Lipogenesis--genetics Male Mechanistic Target of Rapamycin Complex 1--metabolism Mice, Knockout Middle Aged Nephrectomy Prognosis Progression-Free Survival Signal Transduction--genetics Young Adult