TY - GEN AU - Zou,Yuming AU - Sarem,Melika AU - Xiang,Shengnan AU - Hu,Honggang AU - Xu,Weidong AU - Shastri,V Prasad TI - Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling SN - 1471-2407 PY - 2020///0226 KW - A549 Cells KW - Alkaloids KW - chemistry KW - Antineoplastic Agents KW - Apoptosis KW - drug effects KW - Autophagy KW - Cell Survival KW - Drug Discovery KW - methods KW - Drugs, Chinese Herbal KW - Epithelial-Mesenchymal Transition KW - HeLa Cells KW - Humans KW - MAP Kinase Signaling System KW - MCF-7 Cells KW - Neoplasms KW - metabolism KW - Phosphatidylinositol 3-Kinases KW - Proto-Oncogene Proteins c-akt KW - Quinolizines KW - Reactive Oxygen Species KW - Signal Transduction KW - Sophora KW - TOR Serine-Threonine Kinases KW - Matrines N1 - Publication Type: Journal Article UR - https://doi.org/10.1186/s12885-019-6199-7 ER -