TY  - GEN
AU  - Colasante,Gaia
AU  - Lignani,Gabriele
AU  - Brusco,Simone
AU  - Di Berardino,Claudia
AU  - Carpenter,Jenna
AU  - Giannelli,Serena
AU  - Valassina,Nicholas
AU  - Bido,Simone
AU  - Ricci,Raffaele
AU  - Castoldi,Valerio
AU  - Marenna,Silvia
AU  - Church,Timothy
AU  - Massimino,Luca
AU  - Morabito,Giuseppe
AU  - Benfenati,Fabio
AU  - Schorge,Stephanie
AU  - Leocani,Letizia
AU  - Kullmann,Dimitri M
AU  - Broccoli,Vania
TI  - dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice
SN  - 1525-0024
PY  - 2020///1221
KW  - Action Potentials
KW  - Animals
KW  - CRISPR-Associated Protein 9
KW  - genetics
KW  - Cell Line, Tumor
KW  - Disease Models, Animal
KW  - Epilepsies, Myoclonic
KW  - therapy
KW  - Female
KW  - GABAergic Neurons
KW  - metabolism
KW  - Genetic Therapy
KW  - methods
KW  - Hippocampus
KW  - cytology
KW  - Interneurons
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Transgenic
KW  - NAV1.1 Voltage-Gated Sodium Channel
KW  - Seizures
KW  - Transcriptional Activation
KW  - Treatment Outcome
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.ymthe.2019.08.018
ER  -