TY - GEN AU - Abbotts,Rachel AU - Topper,Michael J AU - Biondi,Christopher AU - Fontaine,Daniel AU - Goswami,Reena AU - Stojanovic,Lora AU - Choi,Eun Yong AU - McLaughlin,Lena AU - Kogan,Aksinija A AU - Xia,Limin AU - Lapidus,Rena AU - Mahmood,Javed AU - Baylin,Stephen B AU - Rassool,Feyruz V TI - DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation SN - 1091-6490 PY - 2020///0407 KW - Animals KW - Antineoplastic Agents KW - BRCA1 Protein KW - genetics KW - BRCA2 Protein KW - Carcinoma, Non-Small-Cell Lung KW - drug therapy KW - Cell Line, Tumor KW - Combined Modality Therapy KW - DNA Modification Methylases KW - antagonists & inhibitors KW - DNA Repair KW - drug effects KW - Drug Therapy, Combination KW - Enzyme Inhibitors KW - administration & dosage KW - Female KW - Homologous Recombination KW - Humans KW - Lung Neoplasms KW - Male KW - Mice KW - Phthalazines KW - Poly(ADP-ribose) Polymerase Inhibitors KW - Radiation, Ionizing N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1073/pnas.1903765116 ER -