TY  - GEN
AU  - O'Connor,Caitlin M
AU  - Leonard,Daniel
AU  - Wiredja,Danica
AU  - Avelar,Rita A
AU  - Wang,Zhizhi
AU  - Schlatzer,Daniela
AU  - Bryson,Benjamin
AU  - Tokala,Eesha
AU  - Taylor,Sarah E
AU  - Upadhyay,Aditya
AU  - Sangodkar,Jaya
AU  - Gingras,Anne-Claude
AU  - Westermarck,Jukka
AU  - Xu,Wenqing
AU  - DiFeo,Analisa
AU  - Brautigan,David L
AU  - Haider,Shozeb
AU  - Jackson,Mark
AU  - Narla,Goutham
TI  - Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors
SN  - 1476-5594
PY  - 2020///0619
KW  - Amino Acid Substitution
KW  - Arginine
KW  - genetics
KW  - Calmodulin-Binding Proteins
KW  - metabolism
KW  - Carcinogenesis
KW  - drug effects
KW  - Cell Line, Tumor
KW  - Drug Resistance, Neoplasm
KW  - Humans
KW  - MAP Kinase Signaling System
KW  - Membrane Proteins
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - antagonists & inhibitors
KW  - Molecular Dynamics Simulation
KW  - Mutagenesis, Site-Directed
KW  - Mutation
KW  - Neoplasms
KW  - drug therapy
KW  - Nerve Tissue Proteins
KW  - Protein Kinase Inhibitors
KW  - pharmacology
KW  - Protein Phosphatase 2
KW  - Recombinant Proteins
KW  - Transfection
KW  - Tyrosine
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41388-019-1012-2
ER  -