Chau, Yasmin <br/><br/>
Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5.  [electronic resource] 

 -  PloS one  2019 
 - e0222803 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1932-6203 
<br/><br/><label>Standard No.: </label>10.1371/journal.pone.0222803  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Biocatalysis--drug effects<br/>Cell Line<br/>Cell Line, Tumor<br/>Cyclic GMP--chemistry<br/>Cyclic Nucleotide Phosphodiesterases, Type 5--chemistry<br/>Erectile Dysfunction--drug therapy<br/>Flavonoids--chemical synthesis<br/>Humans<br/>Hypertension, Pulmonary--drug therapy<br/>Male<br/>Models, Chemical<br/>Molecular Structure<br/>Phosphodiesterase 5 Inhibitors--chemical synthesis<br/>Structure-Activity Relationship