A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. [electronic resource]
- Molecular pharmacology 11 2019
- 629-640 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
1521-0111
10.1124/mol.119.115964 doi
ATP Binding Cassette Transporter, Subfamily B--metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1--chemistry ATP Binding Cassette Transporter, Subfamily G, Member 2--metabolism Antineoplastic Agents--chemistry Cytotoxins--chemistry Dose-Response Relationship, Drug HEK293 Cells HeLa Cells High-Throughput Screening Assays--methods Humans Neoplasm Proteins--metabolism Substrate Specificity--drug effects