Antineoplastic Combined Chemotherapy Protocols--therapeutic use Breast Neoplasms--drug therapy Clinical Trials as Topic Cyclophosphamide--therapeutic use Doxorubicin--therapeutic use Estrogens, Conjugated (USP)--therapeutic use Female Fluorouracil--therapeutic use Humans Methotrexate--therapeutic use Neoplasm Metastasis Tamoxifen--therapeutic use