TY  - GEN
AU  - Grievink,Hendrika W
AU  - Heuberger,Jules A A C
AU  - Huang,Fen
AU  - Chaudhary,Rinkal
AU  - Birkhoff,Willem A J
AU  - Tonn,George R
AU  - Mosesova,Sofia
AU  - Erickson,Rebecca
AU  - Moerland,Matthijs
AU  - Haddick,Patrick C G
AU  - Scearce-Levie,Kimberly
AU  - Ho,Carole
AU  - Groeneveld,Geert Jan
TI  - DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers
SN  - 1532-6535
PY  - 2020///1112
KW  - Adolescent
KW  - Adult
KW  - Area Under Curve
KW  - Dose-Response Relationship, Drug
KW  - Double-Blind Method
KW  - Female
KW  - Half-Life
KW  - Humans
KW  - Leukocytes, Mononuclear
KW  - drug effects
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Middle Aged
KW  - Phosphorylation
KW  - Receptor-Interacting Protein Serine-Threonine Kinases
KW  - antagonists & inhibitors
KW  - Young Adult
N1  - Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1002/cpt.1615
ER  -