DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance. [electronic resource]
- The Journal of clinical investigation 11 2019
- 5005-5019 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1558-8238
10.1172/JCI128571 doi
Animals Antineoplastic Combined Chemotherapy Protocols--pharmacology Azacitidine--pharmacology Cell Line, Tumor DNA Methylation Dendritic Cells--metabolism Drug Delivery Systems Female Hematologic Neoplasms--drug therapy Humans Interleukin-3 Receptor alpha Subunit--metabolism Leukemia, Myeloid, Acute--drug therapy Male Mice Mice, Nude Minor Histocompatibility Antigens--metabolism Neoplasm Proteins--metabolism Recombinant Fusion Proteins--pharmacology Tumor Suppressor Proteins--metabolism Xenograft Model Antitumor Assays