TY - GEN AU - Höchsmann,Britta AU - Murakami,Yoshiko AU - Osato,Makiko AU - Knaus,Alexej AU - Kawamoto,Michi AU - Inoue,Norimitsu AU - Hirata,Tetsuya AU - Murata,Shogo AU - Anliker,Markus AU - Eggermann,Thomas AU - Jäger,Marten AU - Floettmann,Ricarda AU - Höllein,Alexander AU - Murase,Sho AU - Ueda,Yasutaka AU - Nishimura,Jun-Ichi AU - Kanakura,Yuzuru AU - Kohara,Nobuo AU - Schrezenmeier,Hubert AU - Krawitz,Peter M AU - Kinoshita,Taroh TI - Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation SN - 1558-8238 PY - 2020///0622 KW - Aged KW - Alleles KW - Antibodies, Monoclonal, Humanized KW - therapeutic use KW - Complement System Proteins KW - immunology KW - Female KW - Gene Deletion KW - Genes, X-Linked KW - Germany KW - Glycosylphosphatidylinositols KW - metabolism KW - Hemoglobinuria, Paroxysmal KW - Hemolysis KW - drug effects KW - Humans KW - Inflammasomes KW - Inflammation KW - Japan KW - Leukocytes KW - Male KW - Membrane Proteins KW - genetics KW - Middle Aged KW - Mutation KW - Point Mutation KW - THP-1 Cells N1 - Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1172/JCI123501 ER -