TY  - GEN
AU  - Cottage,Christopher T
AU  - Peterson,Norman
AU  - Kearley,Jennifer
AU  - Berlin,Aaron
AU  - Xiong,Ximing
AU  - Huntley,Anna
AU  - Zhao,Weiguang
AU  - Brown,Charles
AU  - Migneault,Annik
AU  - Zerrouki,Kamelia
AU  - Criner,Gerald
AU  - Kolbeck,Roland
AU  - Connor,Jane
AU  - Lemaire,Raphael
TI  - Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice
SN  - 2399-3642
PY  - 2020///0414
KW  - Alveolar Epithelial Cells
KW  - metabolism
KW  - Animals
KW  - Cell Proliferation
KW  - Cellular Senescence
KW  - Cyclin-Dependent Kinase Inhibitor p16
KW  - genetics
KW  - Cytokines
KW  - Emphysema
KW  - etiology
KW  - Insulin-Like Growth Factor I
KW  - Lung
KW  - Mice, Inbred C57BL
KW  - Models, Biological
KW  - Promoter Regions, Genetic
KW  - Proto-Oncogene Proteins c-akt
KW  - Pulmonary Disease, Chronic Obstructive
KW  - RNA, Messenger
KW  - Signal Transduction
KW  - Smoking
KW  - adverse effects
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s42003-019-0532-1
ER  -