TY  - GEN
AU  - Cocco,Emiliano
AU  - Schram,Alison M
AU  - Kulick,Amanda
AU  - Misale,Sandra
AU  - Won,Helen H
AU  - Yaeger,Rona
AU  - Razavi,Pedram
AU  - Ptashkin,Ryan
AU  - Hechtman,Jaclyn F
AU  - Toska,Eneda
AU  - Cownie,James
AU  - Somwar,Romel
AU  - Shifman,Sophie
AU  - Mattar,Marissa
AU  - Selçuklu,S Duygu
AU  - Samoila,Aliaksandra
AU  - Guzman,Sean
AU  - Tuch,Brian B
AU  - Ebata,Kevin
AU  - de Stanchina,Elisa
AU  - Nagy,Rebecca J
AU  - Lanman,Richard B
AU  - Houck-Loomis,Brian
AU  - Patel,Juber A
AU  - Berger,Michael F
AU  - Ladanyi,Marc
AU  - Hyman,David M
AU  - Drilon,Alexander
AU  - Scaltriti,Maurizio
TI  - Resistance to TRK inhibition mediated by convergent MAPK pathway activation
SN  - 1546-170X
PY  - 2019///1112
KW  - Adolescent
KW  - Adult
KW  - Animals
KW  - Benzamides
KW  - administration & dosage
KW  - Cell Proliferation
KW  - drug effects
KW  - Cell-Free Nucleic Acids
KW  - Child
KW  - Clinical Trials as Topic
KW  - Drug Resistance, Neoplasm
KW  - Female
KW  - Heterografts
KW  - Humans
KW  - Imidazoles
KW  - Indazoles
KW  - MAP Kinase Signaling System
KW  - Male
KW  - Mice
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - antagonists & inhibitors
KW  - Molecular Targeted Therapy
KW  - Neoplasms
KW  - drug therapy
KW  - Oncogene Proteins, Fusion
KW  - genetics
KW  - Oximes
KW  - Protein Kinase Inhibitors
KW  - Pyrazoles
KW  - Pyridones
KW  - Pyrimidines
KW  - Pyrimidinones
KW  - Receptor, trkA
KW  - Young Adult
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41591-019-0542-z
ER  -