TY - GEN AU - Knott,Gavin J AU - Cress,Brady F AU - Liu,Jun-Jie AU - Thornton,Brittney W AU - Lew,Rachel J AU - Al-Shayeb,Basem AU - Rosenberg,Daniel J AU - Hammel,Michal AU - Adler,Benjamin A AU - Lobba,Marco J AU - Xu,Michael AU - Arkin,Adam P AU - Fellmann,Christof AU - Doudna,Jennifer A TI - Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a SN - 2050-084X PY - 2020///0203 KW - Acidaminococcus KW - enzymology KW - Bacteriophages KW - growth & development KW - CRISPR-Cas Systems KW - drug effects KW - Clostridiales KW - Enzyme Inhibitors KW - metabolism KW - Evolution, Molecular KW - Host-Parasite Interactions KW - Viral Proteins N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.7554/eLife.49110 ER -