TY - GEN AU - Duan,Jingjing AU - Li,Jian AU - Chen,Gui-Lan AU - Ge,Yan AU - Liu,Jieyu AU - Xie,Kechen AU - Peng,Xiaogang AU - Zhou,Wei AU - Zhong,Jianing AU - Zhang,Yixing AU - Xu,Jie AU - Xue,Changhu AU - Liang,Bo AU - Zhu,Lan AU - Liu,Wei AU - Zhang,Cheng AU - Tian,Xiao-Li AU - Wang,Jianbin AU - Clapham,David E AU - Zeng,Bo AU - Li,Zongli AU - Zhang,Jin TI - Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function SN - 2375-2548 PY - 2020///0513 KW - Animals KW - Binding Sites KW - Cations KW - Conserved Sequence KW - Cryoelectron Microscopy KW - Gadolinium KW - pharmacology KW - HEK293 Cells KW - Humans KW - Ion Channel Gating KW - drug effects KW - Kinetics KW - Lanthanum KW - Lipids KW - chemistry KW - Mice KW - Mutation KW - genetics KW - Structure-Activity Relationship KW - TRPC Cation Channels N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1126/sciadv.aaw7935 ER -