Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells. [electronic resource]
- Stem cell reports 08 2019
- 338-351 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2213-6711
10.1016/j.stemcr.2019.06.003 doi
AMP-Activated Protein Kinases--metabolism Bone Morphogenetic Protein 4--pharmacology Cell Differentiation--drug effects Cell Lineage Citric Acid Cycle--drug effects Endoderm--cytology Homeodomain Proteins--genetics Human Embryonic Stem Cells--cytology Humans Mesoderm--cytology Mitochondria--drug effects Oxidative Phosphorylation--drug effects Pyruvic Acid--pharmacology Signal Transduction--drug effects T-Box Domain Proteins--genetics TOR Serine-Threonine Kinases--metabolism Up-Regulation--drug effects