Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity. [electronic resource]
- Molecular cancer therapeutics 10 2019
- 1832-1843 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-8514
10.1158/1535-7163.MCT-18-0048 doi
Animals Antibodies, Monoclonal--therapeutic use Antineoplastic Agents--pharmacology Cell Line, Tumor Cholestyramine Resin--pharmacology Female Gene Expression Regulation--drug effects Humans Ileum--drug effects Liver--drug effects Mice Mice, Inbred BALB C NIH 3T3 Cells Receptor, Fibroblast Growth Factor, Type 4--immunology Signal Transduction--drug effects Sorafenib--pharmacology