TY  - GEN
AU  - Jede,Christian
AU  - Wagner,Christian
AU  - Kubas,Holger
AU  - Weigandt,Markus
AU  - Weber,Christian
AU  - Lecomte,Marc
AU  - Badolo,Lassina
AU  - Koziolek,Mirko
AU  - Weitschies,Werner
TI  - Improved Prediction of in Vivo Supersaturation and Precipitation of Poorly Soluble Weakly Basic Drugs Using a Biorelevant Bicarbonate Buffer in a Gastrointestinal Transfer Model
SN  - 1543-8392
PY  - 2020///0608
KW  - Administration, Oral
KW  - Animals
KW  - Bicarbonates
KW  - chemistry
KW  - Buffers
KW  - Chemical Precipitation
KW  - drug effects
KW  - Drug Delivery Systems
KW  - methods
KW  - Drug Liberation
KW  - physiology
KW  - Female
KW  - Gastrointestinal Absorption
KW  - Gastrointestinal Tract
KW  - Hydrogen-Ion Concentration
KW  - Indazoles
KW  - Ketoconazole
KW  - administration & dosage
KW  - Lapatinib
KW  - Methylcellulose
KW  - analogs & derivatives
KW  - Models, Biological
KW  - Phosphates
KW  - Pyrimidines
KW  - Rats
KW  - Rats, Wistar
KW  - Solubility
KW  - Sulfonamides
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/acs.molpharmaceut.9b00534
ER  -