TY  - GEN
AU  - Aslanis,Vassilios
AU  - Umehara,Kenichi
AU  - Huth,Felix
AU  - Ouatas,Taoufik
AU  - Bharathy,Savita
AU  - Butler,Andrew Avigdor
AU  - Zhou,Wen
AU  - Gadbaw,Brian
TI  - Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjects
SN  - 1432-0843
PY  - 2020///0512
KW  - Adult
KW  - Cytochrome P-450 CYP2C9
KW  - metabolism
KW  - Cytochrome P-450 CYP3A
KW  - Dose-Response Relationship, Drug
KW  - Drug Administration Schedule
KW  - Drug Interactions
KW  - Enzyme Inhibitors
KW  - pharmacokinetics
KW  - Female
KW  - Fluconazole
KW  - Half-Life
KW  - Healthy Volunteers
KW  - Humans
KW  - Janus Kinases
KW  - Male
KW  - Metabolic Clearance Rate
KW  - drug effects
KW  - Middle Aged
KW  - Nitriles
KW  - Pyrazoles
KW  - Pyrimidines
KW  - Signal Transduction
N1  - Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1007/s00280-019-03907-1
ER  -