TY - GEN AU - Chatterjee,Payel AU - Schweizer,Michael T AU - Lucas,Jared M AU - Coleman,Ilsa AU - Nyquist,Michael D AU - Frank,Sander B AU - Tharakan,Robin AU - Mostaghel,Elahe AU - Luo,Jun AU - Pritchard,Colin C AU - Lam,Hung-Ming AU - Corey,Eva AU - Antonarakis,Emmanuel S AU - Denmeade,Samuel R AU - Nelson,Peter S TI - Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage SN - 1558-8238 PY - 2020///0615 KW - Androgens KW - pharmacology KW - BRCA2 Protein KW - deficiency KW - Cellular Senescence KW - drug effects KW - DNA Damage KW - G1 Phase Cell Cycle Checkpoints KW - Gene Amplification KW - Humans KW - Male KW - PC-3 Cells KW - Poly(ADP-ribose) Polymerases KW - genetics KW - Prostatic Neoplasms KW - drug therapy KW - Receptors, Androgen KW - Resting Phase, Cell Cycle N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1172/JCI127613 ER -