The β2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease. [electronic resource]
- Scientific reports 07 2019
- 10062 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/s41598-019-46448-6 doi
Adrenergic beta-Antagonists--pharmacology Apoptosis Cell Nucleus--metabolism Central Nervous System Neoplasms--complications Hemangioblastoma--complications Humans Hypoxia-Inducible Factor 1, alpha Subunit--metabolism Molecular Targeted Therapy Mutation--genetics Neovascularization, Pathologic Propanolamines--pharmacology Signal Transduction Tumor Cells, Cultured Von Hippel-Lindau Tumor Suppressor Protein--genetics von Hippel-Lindau Disease--complications