Linear and Rationally Designed Stapled Peptides Abrogate TLR4 Pathway and Relieve Inflammatory Symptoms in Rheumatoid Arthritis Rat Model. [electronic resource]
- Journal of medicinal chemistry 07 2019
- 6495-6511 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.9b00061 doi
Animals Anti-Inflammatory Agents--chemistry Arthritis, Rheumatoid--drug therapy Drug Design Lipopolysaccharides--immunology Male Mice Peptides--chemistry RAW 264.7 Cells Rats Rats, Inbred Lew Signal Transduction--drug effects Toll-Like Receptor 4--antagonists & inhibitors Tumor Necrosis Factor-alpha--immunology