TY - GEN AU - Ning,Jian-Fang AU - Stanciu,Monica AU - Humphrey,Melissa R AU - Gorham,Joshua AU - Wakimoto,Hiroko AU - Nishihara,Reiko AU - Lees,Jacqueline AU - Zou,Lee AU - Martuza,Robert L AU - Wakimoto,Hiroaki AU - Rabkin,Samuel D TI - Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma SN - 2041-1723 PY - 2019///0909 KW - Animals KW - Antigens, Surface KW - genetics KW - Ataxia Telangiectasia Mutated Proteins KW - Cell Cycle Proteins KW - Cyclin-Dependent Kinases KW - Drug Resistance, Neoplasm KW - Female KW - Glioblastoma KW - drug therapy KW - Homologous Recombination KW - Humans KW - Mice KW - Mice, SCID KW - N-Myc Proto-Oncogene Protein KW - Neoplastic Stem Cells KW - metabolism KW - Poly (ADP-Ribose) Polymerase-1 KW - Poly(ADP-ribose) Polymerase Inhibitors KW - administration & dosage KW - Protein Binding KW - Proto-Oncogene Proteins c-myc KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41467-019-10993-5 ER -