TY  - GEN
AU  - Rath,Abhijit
AU  - Mishra,Akriti
AU  - Ferreira,Victoria Duque
AU  - Hu,Chaoran
AU  - Omerza,Gregory
AU  - Kelly,Kevin
AU  - Hesse,Andrew
AU  - Reddi,Honey V
AU  - Grady,James P
AU  - Heinen,Christopher D
TI  - Functional interrogation of Lynch syndrome-associated MSH2 missense variants via CRISPR-Cas9 gene editing in human embryonic stem cells
SN  - 1098-1004
PY  - 2020///0309
KW  - CRISPR-Cas Systems
KW  - Cell Line, Tumor
KW  - Colorectal Neoplasms, Hereditary Nonpolyposis
KW  - diagnosis
KW  - DNA Damage
KW  - DNA Repair
KW  - Gene Editing
KW  - High-Throughput Nucleotide Sequencing
KW  - Human Embryonic Stem Cells
KW  - metabolism
KW  - Humans
KW  - Microsatellite Instability
KW  - Models, Molecular
KW  - MutS Homolog 2 Protein
KW  - chemistry
KW  - Mutation, Missense
KW  - Protein Conformation
KW  - Signal Transduction
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1002/humu.23848
ER  -