TY  - GEN
AU  - Birkinshaw,Richard W
AU  - Gong,Jia-Nan
AU  - Luo,Cindy S
AU  - Lio,Daisy
AU  - White,Christine A
AU  - Anderson,Mary Ann
AU  - Blombery,Piers
AU  - Lessene,Guillaume
AU  - Majewski,Ian J
AU  - Thijssen,Rachel
AU  - Roberts,Andrew W
AU  - Huang,David C S
AU  - Colman,Peter M
AU  - Czabotar,Peter E
TI  - Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations
SN  - 2041-1723
PY  - 2019///0624
KW  - Antineoplastic Agents
KW  - metabolism
KW  - Bridged Bicyclo Compounds, Heterocyclic
KW  - Crystallization
KW  - Crystallography, X-Ray
KW  - Drug Resistance, Neoplasm
KW  - genetics
KW  - Humans
KW  - Leukemia, Lymphocytic, Chronic, B-Cell
KW  - drug therapy
KW  - Mutation
KW  - Protein Binding
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - antagonists & inhibitors
KW  - Sulfonamides
KW  - Surface Plasmon Resonance
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41467-019-10363-1
ER  -