TY - GEN AU - Hernández-Prat,Anna AU - Rodriguez-Vida,Alejo AU - Juanpere-Rodero,Nuria AU - Arpi,Oriol AU - Menéndez,Silvia AU - Soria-Jiménez,Luis AU - Martínez,Alejandro AU - Iarchouk,Natalia AU - Rojo,Federico AU - Albanell,Joan AU - Brake,Rachael AU - Rovira,Ana AU - Bellmunt,Joaquim TI - Novel Oral mTORC1/2 Inhibitor TAK-228 Has Synergistic Antitumor Effects When Combined with Paclitaxel or PI3Kα Inhibitor TAK-117 in Preclinical Bladder Cancer Models SN - 1557-3125 PY - 2020///0617 KW - Administration, Oral KW - Animals KW - Antineoplastic Combined Chemotherapy Protocols KW - administration & dosage KW - Benzoxazoles KW - Cell Line, Tumor KW - Cell Proliferation KW - drug effects KW - Cell Survival KW - Dose-Response Relationship, Drug KW - Drug Synergism KW - Humans KW - Imidazoles KW - Male KW - Mechanistic Target of Rapamycin Complex 1 KW - antagonists & inhibitors KW - Mechanistic Target of Rapamycin Complex 2 KW - Mice KW - Morpholines KW - Paclitaxel KW - Pyridines KW - Pyrimidines KW - Urinary Bladder Neoplasms KW - drug therapy KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/1541-7786.MCR-18-0923 ER -